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Bio-structures and Biomaterials (Biostructuri si Biomateriale)

Head: Nicanor I. MOLDOVAN, PhD, Ohio State University, Columbus, OH, USA



Mihai Oana Claudia, BA, University of Bucharest, Romania

Alin Velea, PhD, IFIN-HH Bucharest, Romania

Nicoleta Roman, PhD, Ohio State University, Lima Campus, OH, USA

Anca I. Stefan, PhD, Lawrence Technical University, Detroit, MI, USA

Jason Carrier, PhD, Ohio State University, Columbus, OH, USA

Research Directions:

1. Hydrophobic interaction as driving force for self-organization of bio-nanostructures and higher-scale cellular components.

2. Live cells as tools for purposeful processing of biomaterials.


Direction 1:

Mihai C., Velea A., Roman N., Tugulea L., Moldovan N. I. Impact of solute molecular properties on the organization of nearby water: A cellular automata model. D. J. Nanomater. Biostruct. 2012, 7: 469 – 475

Lenormand G., Millet E., Hardin C., Butler J. P., Moldovan N. I. Fredberg J. Dynamics of the cytoskeleton:  How much does water matter? 2011, Physical Review Letters, E , 83:061918.

Direction 2:

N. I. Moldovan, P. Goldschmidt-Clermont, J. Parker-Thornburg , P. E. Kolattukudy, Contribution of Monocytes/Macrophages to Compensatory Neo-Vascularization: Drilling of Metalloelastase-Positive Channels. Circ. Res. 87:378-384, 2000 (Editorial: Mining the Myocardium With Macrophage Drills : A Novel Mechanism for Revascularization, by M. P. Bendeck, Circ. Res. 87:341–343, 2000).

N. I. Moldovan, S. Kulkarni , M. Ferrari. Use of Laser Scanning Cytometry for Analysis of Endothelial Cells Attached to Micropatterned Silicon Surfaces. Sensors and Materials 14:179-187, 2002.

S. Kulkarni, R. Orth, M. Ferrari, N. I. Moldovan. Micropatterning of endothelial cells by guided stimulation with angiogenic factors. Biosensors and Bioelectronics, 2004, 19: 1401-7.

K. E. Orosz, S. Gupta, M. Hassink, M. Abdel-Rahman, L. Moldovan, F. Davidorf, N. I. Moldovan. Delivery of Antiangiogenic and Antioxidant Drugs of Ophthalmic Interest Through a Nanoporous Inorganic Filter. Mol. Vis., 2004, 10: 555-565.

Anghelina M., Krishnan, P., Moldovan, L., Moldovan, N.I. Monocytes/Macrophages Form Branched Cell Columns in Matrigel in Vitro and in Vivo: Implications for Their Role in Neovascularization, Stem Cells Dev. 2004, 13: 665-676.

Anghelina, M., Krishnan P. Moldovan, L. Moldovan, N. I. Monocytes/Macrophages cooperate with progenitor cells during neovascularization and tissue repair: Conversion of cell columns into fibro-vascular bundles Am. J. Pathol., 2006, 168:529-541.

Butt OI; Kutala VK, Kuppusamy P, Moldovan N. I. Tissue engineering of peri-implant neovascularization with bone marrow-derived progenitor cells: Monitoring by in vivo EPR oximetry. Tissue Eng.. 2007, 13:2053-61. (Special Issue on ‘Emerging Technologies and New Basic Science Directions in Tissue Engineering’).

Smith BR, Heverhagen J, Knopp M, Schmalbrock P, Shapiro, J Shiomi M, Moldovan, N. I., Ferrari M, Lee SC. Localization to atherosclerotic plaque and biodistribution of biochemically derivatized superparamagnetic iron oxide nanoparticles (SPIONs) contrast particles for magnetic resonance imaging (MRI). Biomedical Microdevices, 2007, 9:719-27.


The Virtual Institute of Physics of the Foundation "Horia Hulubei"